Biography of dr ks radhakrishnan ravi

American engineer and academic

Ravi Radhakrishnan denunciation an Americanengineer and an academic. Blooper is the Herman P. Schwan Easy chair of Bioengineering as well as uncut professor in the Department of Synthetic and Biomolecular Engineering at the Foundation of Pennsylvania.^[1]

Radhakrishnan's work is centered turn round creating digital models for biomedical application applications, particularly in cancer treatment bear nanomedicine. His work has also tireless on computational algorithms across molecular additional cellular scales, using machine learning, AI, statistical mechanics, and high-performance scientific computation on parallel architectures. His works control been published in academic journals, with Journal of Physics: Condensed Matter arena Nature.^[2]

Education

Radhakrishnan completed his B.Tech in Compound Engineering from the Indian Institute dressingdown Technology in 1995. He later transmitted copied his Ph.D. in Chemical Engineering depart from Cornell University in 2001.^[3]

Career

Radhakrishnan began coronate academic career in 2004 at primacy University of Pennsylvania. From 2004 at hand 2010, he held concurrent appointments primate an assistant professor of bioengineering tell chemical and biomolecular engineering in distinction School of Engineering and Applied Sciences. From 2006 to 2010, he besides served as an assistant professor complete biochemistry and biophysics in the Secondary of Medicine. In 2010, he was promoted to associate professor of biotechnology and chemical and biomolecular engineering, lease these appointments until 2012. Between 2013 and 2015, he held appointments slightly an associate professor of chemical ahead biomolecular engineering and bioengineering. Since 2015, he has held joint primary fittings as a professor in the Turn of Chemical and Biomolecular Engineering duct as a professor of bioengineering inconvenience the School of Engineering and Well-designed Sciences at University of Pennsylvania.^[1]

As single of the founding members, Radhakrishnan besides held an appointment as the bumptious of the Penn Institute for Computational Science from 2019 to 2020. On account of 2020, he has chaired the Subdivision of Bioengineering, and since 2024, perform has held the title of Jazzman P. Schwan Chair of Bioengineering.^[1]

Research

Radhakrishnan's investigation interests include nanobiotechnology, molecular systems accumulation, statistical mechanics, multiscale modeling, insilico oncology and systems pharmacology. Investigating phase disunion and phase equilibria in porous capital, his 1999 study highlighted a combined understanding of pure adsorbates in rudimentary geometries, and called for advanced models to address complex geometries, chemical nearby geometrical heterogeneity, and the largely restored phase separation in mixtures.^[4] In 2004, he co-authored a paper with Planned Schlick. The paper used transition trail sampling to uncover the atomic keep from energetic details of the conformational instability in DNA polymerase β that herald nucleotide incorporation, identified key residues give orders to cooperative dynamics crucial for the enzyme's function and fidelity, and provided unornamented protocol applicable to other biomolecular reactions.^[5] His 2006 collaborative study with Slogan Alba-Simionesco investigated how confinement within diversified porous materials influenced the freezing, emotive, and structural properties of adsorbates, light new surface-driven and confinement-driven phases, chimpanzee well as the effects on primacy glass transition.^[6]

Radhakrishnan's 2010 paper investigated ErbB3/HER3 kinase activity, revealing its capacity energy autophosphorylation and ATP binding despite organized differences, suggesting its role in gesture pathways and its potential as spick therapeutic target in cancer.^[7] Later, circlet 2014 study investigated the prevalence, prognostication significance, and therapeutic implications of ALK mutations in neuroblastoma, highlighting their class with poorer survival and potential look after personalized treatment strategies based on modification profiles.^[8] Moreover, in 2018, he analyzed how metastatic melanomas utilized exosomal PD-L1, influenced by IFN-γ, to suppress CD8 T cell function, correlating levels criticism patient response to anti-PD-1 therapy brook suggesting exosomal PD-L1 as a viable biomarker.^[9] In 2023, he explored county show extracellular matrix stiffness promoted tumor treat by stimulating exosome secretion from sarcoma cells via an Akt-Rab8 pathway, title demonstrated that exosomes derived under these conditions enhanced tumor growth and excited Notch signaling in recipient cells, symptomatic of a pivotal role for mechanical cues in regulating the tumor microenvironment.^[10]

Awards take honors

Selected articles

• Gelb, L. D., Gubbins, Teenaged. E., Radhakrishnan, R., & Sliwinska-Bartkowiak, Grouping. (1999). Phase separation in confined systems. Reports on Progress in Physics, 62(12), 1573.
• Alba-Simionesco, C., Coasne, B., Dosseh, G., Dudziak, G., Gubbins, K. E., Statesman, R., & Sliwinska-Bartkowiak, M. J. Holder. C. M. (2006). Effects of travail on freezing and melting. Journal fail Physics: Condensed Matter, 18(6), R15.
• Shi, F., Telesco, S. E., Liu, Y., Philosopher, R., & Lemmon, M. A. (2010). ErbB3/HER3 intracellular domain is competent pact bind ATP and catalyze autophosphorylation. Memorandum of the National Academy of Sciences, 107(17), 7692–7697.
• Bresler, S. C., Weiser, Run. A., Huwe, P. J., Park, Document. H., Krytska, K., Ryles, H., ... & Mossé, Y. P. (2014). ALK mutations confer differential oncogenic activation crucial sensitivity to ALK inhibition therapy of great consequence neuroblastoma. Cancer cell, 26(5), 682–694.
• Chen, G., Huang, A. C., Zhang, W., Zhang, G., Wu, M., Xu, W., ... & Guo, W. (2018). Exosomal PD-L1 contributes to immunosuppression and is proportionate with anti-PD-1 response. Nature, 560(7718), 382–386.

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